1-Dodecanol → HCID 21523798, compound

HRID 917834Notes

Reaction equation

HRID 917834 reaction equation
[S:1]([C:5]1[C:6]([O:8][C:9](=[O:11])[CH:10]=1)=[O:7])([OH:4])(=[O:3])=[O:2].[CH2:12]([OH:24])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23].[OH-:25].[Na+:26]>O>[CH2:12]([O:24][C:5]([S:1]([OH:4])(=[O:3])=[O:2])([CH2:10][C:9]([O-:8])=[O:11])[C:6]([O-:25])=[O:7])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23].[Na+:26].[Na+:26].[Na+:26]

Participants

5

Reactant 3

HCID 81931-DodecanolHCID 14798Sodium HydroxideHCID 124798802,5-Dioxo-2,5-dihydrofuran-3-sulfonic acid

Product 1

HCID 21523798HCID 21523798, compoundYield 64.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

Sulfomaleic anhydride (10 gm) is mixed with 80 gm (0.45 mole) of n-dodecanol and heated at 100°C for 14 hours. A solution of 7.04 gm of sodium hydroxide in 50 ml water is then added and the mixture heated at 60°C for 2 hours. The heated mixture is then extracted three times with 300 cc portions of acetone (at reflux) and the acetone insoluble fraction is then filtered, washed with additional acetone and dried to give 16.2 gm of the title compound (structure confirmed by NMR and ion exchange of a sample followed by titration with standard sodium hydroxide: neutralization equivalent: found 147.0, theory 149.3).

Workup

  1. temperaturethe mixture heated at 60°C for 2 hours
  2. extractionThe heated mixture is then extracted three times with 300 cc portions of acetone (at reflux)
  3. filtrationthe acetone insoluble fraction is then filtered
  4. washwashed with additional acetone
  5. customdried

Sources & evidence

ORD record
ord-83e831bae99d4793bdc03596dd3df19f
Source dataset
uspto-grants-1976_07
Patent number
US03968110

Reaction notes

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