HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-chloro-3-nitropyridine → 5-Chloro-3-nitro-2-(2,2,3,3-tetrafluoropropionamido)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-chloro-3-nitropyridine | HCID 224168 | — |
| Reactant | 2,2,3,3-Tetrafluoropropanoyl chloride | HCID 2776744 | — |
| Product | 5-Chloro-3-nitro-2-(2,2,3,3-tetrafluoropropionamido)pyridine | HCID 20355506 | — |
Reaction Steps
5-Chloro-3-nitro-2-aminopyridine is reacted with 2,2,3,3-tetrafluoropropionyl chloride to yield 5-chloro-3-nitro-2-(2,2,3,3-tetrafluoropropionamido)pyridine, which when hydrogenated yields 6-chloro-1-hydroxy-2-(1,1,2,2-tetrafluoroethyl)-1H-imidazo-(4,5-b)pyridine. This compound is reacted with trimethylamine to prepare 6-chloro-1-hydroxy-2-(1,1,2,2-tetrafluoroethyl)-1H-imidazo-(4,5-b)pyridine trimethylamine salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03968116 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-5d1330c3106b4c4780ad0488bf559398 |
| Source note | uspto-grants-1976_07 |