Isopropylamine → HCID 54045198, compound

HRID 917870Notes

Reaction equation

HRID 917870 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH:19]3[O:21][CH2:20]3)=[CH:13][CH:12]=2)[C:9]([C:22]([O:24][CH3:25])=[O:23])=[C:8]([CH3:26])[N:7]([CH3:27])[C:6]=1[CH3:28])=[O:4].[CH:29]([NH2:32])([CH3:31])[CH3:30]>>[CH3:1][O:2][C:3]([C:5]1[CH:10]([C:11]2[CH:12]=[CH:13][C:14]([O:17][CH2:18][CH:19]([OH:21])[CH2:20][NH:32][CH:29]([CH3:31])[CH3:30])=[CH:15][CH:16]=2)[C:9]([C:22]([O:24][CH3:25])=[O:23])=[C:8]([CH3:26])[N:7]([CH3:27])[C:6]=1[CH3:28])=[O:4]

Participants

3

Reactant 2

HCID 6363IsopropylamineHCID 53673338HCID 53673338, compound

Product 1

HCID 54045198HCID 54045198, compoundYield 90%

Procedure

Eleven grams of 1,2,6-trimethyl-4-[4-(2,3-epoxypropoxy)-phenyl]-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester (melting point 126°), 3 g of isopropylamine and 40 ml of alcohol are heated at reflux overnight, concentrated in vacuo and treated with acetone. The product precipitates as the hydrochloride salt, white crystals of melting point 211°-212°C, in a yield of 90% of theory.

Workup

  1. temperatureat reflux overnight
  2. concentrationconcentrated in vacuo
  3. additiontreated with acetone
  4. customThe product precipitates as the hydrochloride salt, white crystals of melting point 211°-212°C, in a yield of 90% of theory

Sources & evidence

ORD record
ord-f33f36186bac417fa8f10272afe6594a
Source dataset
uspto-grants-1976_07
Patent number
US03968117

Reaction notes

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