HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propanoic acid, 2-bromo-2-methyl-, ethyl ester → HCID 68130215, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propanoic acid, 2-bromo-2-methyl-, ethyl ester | HCID 11745 | — |
| Reactant | 3,5-Diethyl 1,4-dihydro-4-(4-hydroxyphenyl)-2,6-dimethyl-3,5-pyridinedicarboxylate | HCID 619963 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 68130215 | HCID 68130215 | — |
Reaction Steps
A solution of 2.3 g of sodium in 120 ml of alcohol is treated with 34.5 g of 2,6-dimethyl-4-(4-hydroxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester and with 21.5 g of α-bromo-isobutyric acid ethyl ester added from a dropping funnel. The mixture is boiled overnight, added to water and extracted with ether. White crystals of melting point 215°C (benzene) are obtained from the evaporation residue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03968117 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-364175ac160a4607bf6e99f8e25d6c29 |
| Source note | uspto-grants-1976_07 |