Cyclamate → HCID 53757270, compound

Participants

Reaction Steps

Following a procedure similar to that of Example 1E but using 28.53 g. of 1-(4-hydroxyphenyl)-2-phenylindole, 300 ml. of chlorobenzene, 5.5 g. of sodium methoxide in 50 ml. of dry methyl alcohol, and N-(2-chloroethyl)pyrrolidine in 100 ml. of chlorobenzene there was obtained 36 g. of crude product, a solution of 35 g. of which was dissolved in hot acetone, treated with a solution of 18 g. of cyclohexanesulfamic acid, diluted with 200 ml. of ether to give, on recrystallization from isopropyl alcohol, 25.8 g. of 1 -{4-[2-(1-pyrrolidyl)ethoxy]-phenyl}-2-phenylindole cyclohexane sulfamate; m.p. 152.5°-153.5°C.

Provenance & Evidence