Sulfuric Acid → HCID 21421165, compound

HRID 917902Notes

Reaction equation

HRID 917902 reaction equation
[O:1]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O[C:17]([CH3:22])([CH3:21])[C:18]([OH:20])=[O:19].S(=O)(=O)(O)O>O>[O:1]([CH2:8][C:9]1[CH:10]=[CH:11][C:12]([O:15][C:17]([CH3:22])([CH3:21])[C:18]([OH:20])=[O:19])=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 116712-Hydroxyisobutyric acidHCID 3161774-(phenoxymethyl)phenol

Product 1

HCID 21421165HCID 21421165, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 20 g. of 4-phenoxymethylphenol and 13.2 g. of the ethyl ester of 2-hydroxyisobutyric acid is combined with 15 g. of sulfuric acid, and the reaction mixture is agitated for 2 hours at 50°-60°. After cooling, the mixture is combined with water and worked up as usual, obtaining the ethyl ester of 2-(4-phenoxymethylphenoxy)-2methyl-propionic acid.

Workup

  1. additionA mixture of 20 g
  2. temperatureAfter cooling

Sources & evidence

ORD record
ord-d796e3b8bd1c41a08b43777bdd3b1cf6
Source dataset
uspto-grants-1976_07
Patent number
US03968143

Reaction notes

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