HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzyl Alcohol → 2-(4-Phenoxymethylphenoxy)-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzyl Alcohol | HCID 125 | — |
| Reactant | Phenol | HCID 996 | — |
| Reactant | Ethyl 2-bromopropionate | HCID 79040 | — |
| Reactant | 2-[4-(Hydroxymethyl)phenoxy]propanoic acid | HCID 351924 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 2-(p-Bromomethylphenoxy)-propionic acid | HCID 20452369 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(4-Phenoxymethylphenoxy)-propionic acid | HCID 21421173 | — |
Reaction Steps
2.3 g. of sodium is dissolved in 250 ml. of absolute ethanol; 9.4 g. of phenol and 28.6 g. of the ethyl ester of 2-(p-bromomethylphenoxy)-propionic acid [obtainable by reacting p-hydroxybenzyl alcohol with ethyl 2-bromopropionate to the ethyl ester of 2-(p-hydroxymethylphenoxy)-propionic acid and subsequent reaction with SOBr2 ] are added thereto, and the mixture is refluxed for 3 hours and evaporated. The usual working-up procedure yields the ethyl ester of 2-(4-phenoxymethylphenoxy)-propionic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03968143 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-073283f3118b4ffb8cf30cfddf88b6ba |
| Source note | uspto-grants-1976_07 |