Ethanol → 2-(4-Phenoxymethylphenoxy)-propionic acid

HRID 917904Notes

Reaction equation

HRID 917904 reaction equation
[O:1]([CH2:8][C:9]1[CH:19]=[CH:18][C:12]([O:13][CH:14]([CH3:17])[C:15]#N)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)C.[OH-:23].[K+].[OH2:25]>>[O:1]([CH2:8][C:9]1[CH:19]=[CH:18][C:12]([O:13][CH:14]([CH3:17])[C:15]([OH:25])=[O:23])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 4

HCID 702EthanolHCID 962WaterHCID 14797Potassium HydroxideHCID 214211642-(4-Phenoxymethylphenoxy)-propionitrile

Product 1

HCID 214211732-(4-Phenoxymethylphenoxy)-propionic acid

Procedure

One gram of 2-(4-phenoxymethylphenoxy)-propionitrile (obtainable from 4-phenoxymethylphenol and 2-bromopropionitrile) is refluxed in 15 ml. of ethanol and 2 ml. of water with 2 g. of KOH for 40 hours. The mixture is then evaporated and worked up as usual, yielding 2-(4-phenoxymethylphenoxy)-propionic acid.

Workup

  1. customThe mixture is then evaporated

Sources & evidence

ORD record
ord-06a0f91f5c7847769c07e2168dc21cc5
Source dataset
uspto-grants-1976_07
Patent number
US03968143

Reaction notes

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