HCID 21524237, compound → HCID 21524245, compound

Participants

Reaction Steps

While cooling well, 17.9 g of 2-(3-chloro-4-cyclohexylphenyl)-glutaric acid are dissolved in 90 ml of 100% sulfuric acid and the solution is kept overnight at 35°C, then cautiously poured out over ice and the aqueous mixture is extracted with ethyl acetate and evaporated. The remaining crystals are recrystallized from toluene, to yield 12.2 g of 4-oxo-6-cyclohexyl-7-chloro-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid melting at 204°-205°C, of the formula ##SPC8##

Provenance & Evidence