HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrafluoro-m-phenylenediamine dihydrochloride → 3-(2-Imidazolyl)propylguanidine sulphate monohydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| Reactant | S-methyl isothiourea hemisulfate | HCID 6604939 | — |
| Reactant | 3-(1H-Imidazol-2-yl)propan-1-amine | HCID 13290797 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(2-Imidazolyl)propylguanidine sulphate monohydrate | HCID 178512791 | — |
Reaction Steps
A solution of 2-(3-aminopropyl)imidazole, prepared from its dihydrochloride (0.9 g) by means of an ion-exchange resin (OH-), and S-methylthiouronium sulphate (1.26 g) in water (20 ml) is heated under reflux for 18 hours. The product, isolated in a manner similar to that described in Example 1, is recrystallized from aqueous ethanol yielding 3-(2-imidazolyl)propylguanidine sulphate monohydrate, m.p. 260°-262°C (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03968216 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-35654090943f4b968938404e38ee6676 |
| Source note | uspto-grants-1976_07 |