Methanol → 3-(3-Pyrazolyl) propylguanidine hemisulphate

HRID 917956Notes

Reaction equation

HRID 917956 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:9]=[CH:8][NH:7][N:6]=1.[S:10]([O-:14])([O-:13])(=[O:12])=[O:11].CS[C:17]([NH2:19])=[NH2+:18].CS[C:22]([NH2:24])=[NH2+:23].CO>C(O)C>[S:10]([OH:14])([OH:13])(=[O:12])=[O:11].[NH:7]1[CH:8]=[CH:9][C:5]([CH2:4][CH2:3][CH2:2][NH:1][C:17]([NH2:19])=[NH:18])=[N:6]1.[NH:7]1[CH:8]=[CH:9][C:5]([CH2:4][CH2:3][CH2:2][NH:1][C:22]([NH2:24])=[NH:23])=[N:6]1

Participants

5

Reactant 3

HCID 887Methanol2×HCID 6604939S-methyl isothiourea hemisulfateHCID 1785109273-(1H-Pyrazol-3-yl)propan-1-amine

Product 1

HCID 1785127903-(3-Pyrazolyl) propylguanidine hemisulphate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

An intimate mixture of 3-(3-aminopropyl)pyrazole (4.7 g) and S-methylthiouronium sulphate (4.9 g) is fused at 140°C for one hour. After cooling, methanol is added and the filtered methanol solution is subsequently diluted with ethanol. The solid obtained is recrystallised from methanol-ethanol affording 3-(3-pyrazolyl) propylguanidine hemisulphate, m.p. 210°C.

Workup

  1. temperatureAfter cooling
  2. customThe solid obtained
  3. customis recrystallised from methanol-ethanol

Sources & evidence

ORD record
ord-a9a5757d3be3427f83411ce039bc66e8
Source dataset
uspto-grants-1976_07
Patent number
US03968216

Reaction notes

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