2-(2-Aminoethyl)thiazole → HCID 178512787, compound

HRID 917958Notes

Reaction equation

HRID 917958 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[S:5][CH:6]=[CH:7][N:8]=1.[S:9]([O-:13])([O-:12])(=[O:11])=[O:10].CS[C:16]([NH2:18])=[NH2+:17].CS[C:21]([NH2:23])=[NH2+:22]>>[S:9]([OH:13])([OH:12])(=[O:11])=[O:10].[S:5]1[CH:6]=[CH:7][N:8]=[C:4]1[CH2:3][CH2:2][NH:1][C:16]([NH2:18])=[NH:17].[S:5]1[CH:6]=[CH:7][N:8]=[C:4]1[CH2:3][CH2:2][NH:1][C:21]([NH2:23])=[NH:22]

Participants

3

Reactant 2

HCID 876532-(2-Aminoethyl)thiazoleHCID 6604939S-methyl isothiourea hemisulfate

Product 1

HCID 178512787HCID 178512787, compound

Procedure

An intimate mixture of 2-(2-aminoethyl)thiazole (4.5 g) and S-methylthiouronium sulphate (9.8 g) is heated at 140°-150°C for 1 hour. Extraction with ethanol and cooling affords the crude product, m.p. 130°-135°C. Recrystallization from ethanol gives 2-(2-thiazolyl)ethylguanidine hemisulphate, m.p. 143°-145°C.

Workup

  1. temperatureis heated at 140°-150°C for 1 hour
  2. extractionExtraction with ethanol
  3. temperaturecooling
  4. customaffords the crude product, m.p. 130°-135°C
  5. customRecrystallization from ethanol

Sources & evidence

ORD record
ord-559f35e328a64c7ca6fb1100778b92e5
Source dataset
uspto-grants-1976_07
Patent number
US03968216

Reaction notes

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