反应详情

The product, crude 21-(2'-cyanoethoxy)-5α-pregnane-3,11,20-trione (0;80 g.) was treated with chloroiridic acid solution (24 ml.). The mixture was refluxed for 24 hours cooled and partitioned between water and ether. The organic layer was washed with saturated aqueous sodium bicarbonate, water, dried (Na2SO4) and evaporated. The residue was subjected to preparative t.l.c. EtOAc, petrol (1:1) to give title compound (0.2 g.) as a white foam, [α]D + 85° (c 1.1).

1. temperatureThe mixture was refluxed for 24 hours
2. temperaturecooled
3. custompartitioned between water and ether
4. washThe organic layer was washed with saturated aqueous sodium bicarbonate, water
5. dry with materialdried (Na2SO4)
6. customevaporated