Toluene → 1-(2,4,6-Trimethyl-3-pyridinyl)-1,3-butanedione

Participants

Reaction Steps

A mixture of 172.0 g of 3-acetyl-collidine, 4.5 l of anhydrous toluene, 195 g of ethyl acetate and 282.5 g of potassium tert.-butylate is heated at 100° for 4 hours under nitrogen. The reaction mixture is cooled and poured into 1/2 l of ice water and 140 ml of acetic acid, and the phases are separated and worked up in the customary manner to give 186.1 g of 2,4,6-trimethyl-nicotinoyl-acetone ##SPC8##

Provenance & Evidence