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Hydrochloric Acid → 1-(2-Methyl-5-pyridyl)-3-chloro-butan-1-ol hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | 1-(6-Methylpyridin-3-yl)butane-1,3-dione | HCID 20212814 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-(2-Methyl-5-pyridyl)-3-chloro-butan-1-ol hydrochloride | HCID 21522724 | — |
反応手順
A suspension of the sodium salt of 6-methyl-nicotinoyl-acetone in anhydrous toluene is saturated with hydrogen chloride and then reacted with thionyl chloride in a known manner. Reduction of the reaction product gives 1-(2-methyl-5-pyridyl)-3-chloro-butan-1-ol hydrochloride which is used without additional purification
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03969363 |
| 出典データセット | uspto-grants-1976_07 |
| ORD ID | ord-09cc5159f43545209b5bb40d30dae3f6 |
| 出典メモ | uspto-grants-1976_07 |