Quinone → HCID 13901327, compound

Participants

Reaction Steps

A solution of 108 g. (1 mole) of p-benzoquinone in 1 liter of isobutyraldehyde is added dropwise with stirring to a refluxing solution of 500 ml. of isobutyraldehyde containing 5 ml. of triethylamine. The total addition and heating time is five hours. The excess isobutyraldehyde is stripped in vacuo leaving a crude oil that crystallized on standing. Trituration with cold chloroform gives 125 g. (70%) of product: m.p. 78°-81°C., nmr indicated the material to be 90-95% desired compound. A sample recrystallized from chloroform had a m.p. of 97°-99°C.

Provenance & Evidence