Sodium Hydroxide → HCID 21522824, compound

HRID 918099Notes

Reaction equation

HRID 918099 reaction equation
C([O:3][C:4](=[O:22])[CH2:5][C:6]1([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[O:10][C:9]2[CH:11]=[CH:12][C:13]([Cl:15])=[CH:14][C:8]=2[O:7]1)C.[OH-].[Na+]>C(O)C>[C:16]1([C:6]2([CH2:5][C:4]([OH:22])=[O:3])[O:10][C:9]3[CH:11]=[CH:12][C:13]([Cl:15])=[CH:14][C:8]=3[O:7]2)[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 131710393HCID 131710393, compound

Product 1

HCID 21522824HCID 21522824, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 32 g. of ethyl(2-phenyl-5-chloro-1,3-benzodioxol-2-yl)acetate, 200 cc. of 95% ethanol and 150 cc. of 4% NaOH is refluxed for 2 hours. The alcohol is then removed under vacuum and, after cooling, the mixture is acidified with dilute HCl. The precipitated solid is filtered off and recrystallised from benzene-hexane, m.p. 117°-119°C.

Workup

  1. additionA mixture of 32 g
  2. customThe alcohol is then removed under vacuum
  3. temperatureafter cooling
  4. filtrationThe precipitated solid is filtered off
  5. customrecrystallised from benzene-hexane, m.p. 117°-119°C.

Sources & evidence

ORD record
ord-ef664a4dbe6d45ef90d8cd0c3a64abbc
Source dataset
uspto-grants-1976_07
Patent number
US03969368

Reaction notes

Loading…