Ethanol → HCID 21522957, compound

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Reaction Steps

To a cooled solution of 2.3g (0.01 mole) of product of Example 2 in 50 ml of anhydrous ethanol 0.48g (0.01 mole) of 50% sodium hydride is added in portions. After the evolution of hydrogen has ceased, 1.5g (0.01 mole) of 2-(dimethylamino) ethyl bromide is added dropwise, and the mixture is refluxed with stirring for 3 hours. The solvent is removed in vacuo, the residue is mixed with 25 ml of water and the mixture extracted with chloroform. The chloroform extract is washed with water, dried (MgSO4), and concd. to give 3-[2-(dimethylamino)ethoxy]-1,1-dichloro-1a, 2,7,7a-tetrahydro[1H]-cyclopropa[b]naphthalene.

Provenance & Evidence