1-Chloro-4-iodobenzene → 4-Acetyl-4'-chloro-2-nitrobiphenyl

HRID 918132ノート

反応式

HRID 918132 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][CH:3]=1.[CH3:9][C:10]([C:12]1[CH:17]=[CH:16][C:15](Br)=[C:14]([N+:19]([O-:21])=[O:20])[CH:13]=1)=[O:11]>CO>[C:10]([C:12]1[CH:17]=[CH:16][C:15]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)=[C:14]([N+:19]([O-:21])=[O:20])[CH:13]=1)(=[O:11])[CH3:9]

参加物

4

反応物 2

HCID 125101-Chloro-4-iodobenzeneHCID 877371-(4-Bromo-3-nitrophenyl)ethan-1-one

生成物 1

HCID 213205634-Acetyl-4'-chloro-2-nitrobiphenyl

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

4-chloroiodobenzene and 4-bromo-3-nitroacetophenone were reacted in an analogous manner to that described in Example 1 (a) to give the novel intermediate 4-acetyl-4'-chloro-2-nitrobiphenyl, m.p. 103° - 105°C. (from methanol). This compound was reduced with stannous chloride and concentrated hydrochloric acid in an analogous manner to that described in Example 1 (b) to give the novel intermediate 4-acetyl-2-amino-4'-chlorobiphenyl, m.p. 139° - 140°C. (from methanol). This compound was converted to the novel intermediate 4-acetyl-4'-chloro-2-hydroxybiphenyl and thence to the novel intermediate 4-acetyl-4'-chloro-2-methoxybiphenyl, b.p. 167° - 170°C./0.4 mm., by diazotization and methylation methods analogous to those described in Example 2.

出典と根拠

ORDレコード
ord-c1e4dbf29d0647a8a20317c0d36d4891
出典データセット
uspto-grants-1976_07
特許番号
US03969402

反応ノート

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