Formaldehyde → HCID 21523290, compound

Participants

Reaction Steps

To a solution of isobutanol (19.2 g., 0.26 mole) and N-benzyl-N-methylamine (30 g., 0.25 mole) is added excess 40 percent formaldehyde (25 g.). The mixture reacts exothermically, and two layers form. Potassium carbonate is added to form a saturated aqueous layer. The mixture is stirred overnight, then extracted thoroughly with diethyl ether. The ether layer is dried, then evaporated under vacuum to provide a residual oil. The residue is distilled under vacuum to provide N-benzyl-N-methylaminomethyl isobutyl ether, b.p. 72°-77° C. at 1.5 mm. Hg as a clear liquid. The structure is established by nuclear magnetic resonance analysis.

Provenance & Evidence