反应详情

A mixture of 12.7 g. of N-benzylisatoic anhydride, 5.8 g. of 2-methylmercapto-imidazoline and 2 pellets of sodium hydroxide in 200 ml. of dioxane was refluxed for 2 hours. While still hot, the mixture was then filtered through Celite and the filtrate concentrated to about 50 ml. volume. 50 ml. of diethyl ether was added and the crystalline precipitate removed by filtration. The residue was dissolved in methylene chloride, treated with charcoal, filtered through alumina, and the filtrate evaporated. The residue was crystallized from methylene chloride/diethyl ether to obtain the heading compound, m.p. 203°-205°C.

1. additionA mixture of 12.7 g
2. filtrationWhile still hot, the mixture was then filtered through Celite
3. concentrationthe filtrate concentrated to about 50 ml
4. additionof diethyl ether was added
5. customthe crystalline precipitate removed by filtration
6. dissolutionThe residue was dissolved in methylene chloride
7. additiontreated with charcoal
8. filtrationfiltered through alumina
9. customthe filtrate evaporated
10. customThe residue was crystallized from methylene chloride/diethyl ether
11. customto obtain the heading compound, m.p. 203°-205°C.