Ethanol → HCID 21834282, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 0.1 m. of potassium hydroxide in water is added to an ethanol (100 ml.)-water (175 ml.) mixture containing 15.4 g. (0.1 m.) of 3-amino-4-nitrophenol. The mixture is then heated to 50°C. at which point a solution of 0.1 m. of 4-chloropyridine in 75 ml. of ethanol is added dropwise over a 45 minute period. Then the mixture is heated at reflux for 18 hours, cooled and worked up to give a crystalline yellow solid, m.p. 170°-175°C. of 5-(4-pyridyloxy)-2-nitroaniline.

Provenance & Evidence