HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzaldehyde → p-(2-(Dimethylamino)ethoxy)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzaldehyde | HCID 126 | — |
| Reactant | 2-Chloro-N,N-dimethylethylamine | HCID 7901 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | p-(2-(Dimethylamino)ethoxy)benzaldehyde | HCID 84823 | 46.6% |
Reaction Steps
The reaction between 61.0 g (0.50 mole) of 4-hydroxybenzaldehyde, 24.0 g of 50% NaH, and 341 ml of 2.2 N (0.75 mole) 2-dimethylaminoethyl chloride in toluene in a procedure described for Example 2, part A, gives 45.0 g (46%) of colorless product, bp 140°-142°/2 mm. Lit. bp 185°-187°/15 mm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03969527 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-a0afadffb96c48149c2c96f09f860a16 |
| Source note | uspto-grants-1976_07 |