HCID 21521307, compound → 1,2,3,4-Tetrahydro-1-methyl-7-propyl-8-quinolinol

Participants

Reaction Steps

Into a stainless steel autoclave, one introduces 37.3 g of paratoluenesulfonate of N-methyl-7-propyl-8-hydroxyquinoline (0.1 mole) in 120 ml of water, and 5 g of Raney nickel. The hydrogenation is carried out under an 80 kg/cm2 hydrogen pressure. After absorption of the hydrogen, one cools and filters off the catalyst; one neutralizes the filtrate with an ammonia solution, resulting in the formation of a grayish-white precipitate that one separates and distills under high vacuum. One collects 8 g of a colorless liquid that distills at 180°-110°C under a 0.5 mm Hg pressure. One obtains a yield of 36%.

Provenance & Evidence