Methyl Bromide → HCID 21521290, compound

Participants

Reaction Steps

Into a tube, one introduces 7.5 g of N-methyl-1,2,3,4-tetrahydro-7-propyl-8-hydroxyquinoline (i.e. 0.035 mole) and 4 g of methyl bromide (i.e. 0.035 mole). One adds 10 ml of acetonitrile, one seals the tube and one heats in an oil bath, at 70°C, for 90 hours. After cooling, one dries the compound that is formed, washes with anhydrous ether, and recrystallizes in boiling isopropanol (1 g of product, 2 ml of alcohol). One collects whitish crystals, which one washes again with ether, then one dries the resulting quaternary salt in a drier over sulfuric acid. One obtains 8 g of product, i.e. a yield of 735/1000.

Provenance & Evidence