Dabco → HCID 12760247, compound

Participants

Reaction Steps

To a stirred mixture of methyl 2-benzimidazolecarbamate (19.1 parts) and triethylenediamine (0.1 part) in chloroform (300 parts) was slowly added 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane (11.1 parts). The reaction mixture was stirred at room temperature overnight, filtered and the solvent removed from the filtrate under reduced pressure. The residue from the filtrate was triturated with hexane and the product methyl 1-{5-[2-(methoxycarbonylamino)-1-benzimidazolylcarbonylamino]-1,3,3-trimethylcyclohexylmethylcarbamoyl}-2- benzimidazolecarbamate (28.5 parts) was collected by filtration. It exhibited a melting point of 82°-83°C.

Provenance & Evidence