HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylene Glycol → 4-[alpha-amino-alpha-amino-alpha-phenyl-o-tolyl]-5-ethyl-4H-1,2,4-triazole-3-carboxaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylene Glycol | HCID 8117 | — |
| Reactant | Hydrazine, propyl- | HCID 42007 | — |
| Reactant | 8-chloro-6-(o-chlorophenyl)-1-cyclopropyl-4H-s-triazolo[4,3-a][1,4] benzodiazepine | HCID 86733715 | — |
| Product | 4-[alpha-amino-alpha-amino-alpha-phenyl-o-tolyl]-5-ethyl-4H-1,2,4-triazole-3-carboxaldehyde | HCID 21521604 | — |
Reaction Steps
In the manner given in Examples 1-7, above, 1ethyl-6-phenyl-4H-s-triazolo[ 4,3-a][1,4]benzodiazepine (III) in diethylene glycol is treated with propyl hydrazine to obtain both A and B 4-[α-amino-α-amino-α-phenyl-o-tolyl]-5-ethyl -4H-1,2,4-triazole-3-carboxaldehyde, propylhydrazone, which is separated by column chromatography into the two diastereomers A and B.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03970666 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-46d02198d7e544e88e3855af5082bcc9 |
| Source note | uspto-grants-1976_07 |