Dichloromethane → Methyl 8-cyano-2-[(2,2-diethoxyethyl)sulfanyl]octanoate

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Reaction Steps

The starting material is prepared as follows: To the mixture of 13.6 g of methyl 2-bromo-8-cyano-octanoate, 11.6 g of 2,2-diethoxy-ethylmercaptan and 150 ml of methylene chloride, 5.56 g of triethylamine are added dropwise while stirring. After overnight-stirring at room temperature the mixture is evaporated, the residue triturated with diethyl ether, washed with water, dried and evaporated, to yield the methyl 2-(2,2-diethoxyethylmercapto)-8-cyano-octanoate showing NMR bands aft 4.58, 3.71 and 2.75 ppm.

Provenance & Evidence