(S)-Ethyl 3-amino-3-phenylpropanoate → (R)-Ethyl 3-amino-3-phenylpropanoate

Participants

Reaction Conditions

Reaction Steps

In a 25 ml flask, 13.0 g of D-β-phenylalanine ethyl ester was charged under nitrogen, and sodium-potassium alloy (Na : K = 56 : 44 by weight) (0.1 g) was added thereto. The mixture was stirred at 20°C for 3 hours. The reaction mixture was treated as in Example 11 to give 12.1 g of racemic β-phenylalanine ethyl ester. B.P. 95° to 96°C/0.6 mmHg. [α]D25 -0.1° (neat).

Provenance & Evidence