Formaldehyde → 1-(4-Fluorophenyl)-3-hydroxy-2-methylpropan-1-one

HRID 918283노트

반응식

HRID 918283 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][CH3:10])=[CH:4][CH:3]=1.[CH2:12]=[O:13].C(=O)([O-])[O-].[K+].[K+]>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:11])[CH:9]([CH3:10])[CH2:12][OH:13])=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 712FormaldehydeHCID 11430Potassium CarbonateHCID 680044-Fluoropropiophenone

생성물 1

HCID 215218911-(4-Fluorophenyl)-3-hydroxy-2-methylpropan-1-one

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 45.7 g. (0.3 mole) of 4'-fluoropropiophenone, 9 g. (0.3 mole) of paraformaldehyde, 4 g. (0.03 mole) of anhydrous potassium carbonate and 200 ml. of methyl alcohol is stirred at 35°C for 2 days. The reaction is quenched in water and acidified with hydrochloric acid. The product is extracted into benzene. The benzene layer is washed with water and concentrated in vacuo to give 4'-fluoro-3-hydroxy-2-methylpropiophenone.

후처리

  1. additionA mixture of 45.7 g
  2. customThe reaction is quenched in water
  3. extractionThe product is extracted into benzene
  4. washThe benzene layer is washed with water
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-81e9f218dbf8468a9b5ce1cf26fc037b
출처 데이터셋
uspto-grants-1976_07
특허 번호
US03970693

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