HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 918286Generated: October 25, 2026
Aluminum(III) Chloride → 5-Fluoro-2-methylindan-1-one
https://huagongshe.com/reaction/918286
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 2-Bromo-1-(4-fluorophenyl)-2-methylpropan-1-one | HCID 13113175 | — |
| Solvent | Carbon Disulfide | HCID 6348 | — |
| Product | 5-Fluoro-2-methylindan-1-one | HCID 3016257 | — |
Reaction Steps
To a slurry of 120.2 g. (0.90 mole) of anhydrous aluminum chloride in 54 ml. of carbon disulfide is added 122.6 g. (0.50 mole) of 2-bromo-4'-fluoro-2-methylpropiophenone at 15° to 20°C over 1 hour. The mixture is warmed to 50°C over 1 hour, stirred at 50°C for 3 hours and quenched in ice. The product is extracted into toluene. The toluene layer is washed with aqueous sodium hydroxide and water and concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US03970693 |
|---|
| Source dataset | uspto-grants-1976_07 |
|---|
| ORD ID | ord-49fe12b1b1f14933a143cba92edc8773 |
|---|
| Source note | uspto-grants-1976_07 |
|---|
