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Fluorobenzene → 3-Chloro-1-(4-fluorophenyl)-2-methylpropan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Fluorobenzene | HCID 10008 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 反応物 | 3-Chloro-2-methylpropanoyl chloride | HCID 12417487 | — |
| 生成物 | 3-Chloro-1-(4-fluorophenyl)-2-methylpropan-1-one | HCID 21521890 | — |
反応手順
To a slurry of 22.7 g. (0.17 mole) of anhydrous aluminum chloride and 9.6 g. (0.10 mole) of fluorobenzene is added 14.1 g. (0.10 mole) of β-chloroisobutyrylchloride over 30 minutes at 20° to 25°C. The mixture is aged for 30 minutes at 20° to 25°C and then quenched in ice. The product is extracted into hexane. The hexane layer is dried over anhydrous sodium sulfate and concentrated in vacuo to give 3-chloro-4'-fluoro-2-methylpropiophenone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03970693 |
| 出典データセット | uspto-grants-1976_07 |
| ORD ID | ord-4c423730beba48a7a4ec648a407851e8 |
| 出典メモ | uspto-grants-1976_07 |