HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 918290Generated: October 25, 2026
Sulfuric Acid → 5-Fluoro-2-methylindan-1-one
https://huagongshe.com/reaction/918290
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 3-Chloro-1-(4-fluorophenyl)-2-methylpropan-1-one | HCID 21521890 | — |
| Product | 5-Fluoro-2-methylindan-1-one | HCID 3016257 | — |
Reaction Steps
Ten grams (0.05 mole) of 3-chloro-4'-fluoro-2-methylpropiophenone is added to 20 ml. of concentrated sulfuric acid at 20°-25°C and the mixture is warmed to 50°C. After stirring for 3 hours at 50°C, the reaction is quenched in ice. The product is extracted into hexane. The hexane layer is concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US03970693 |
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| Source dataset | uspto-grants-1976_07 |
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| ORD ID | ord-b7bd6898c544477b946579d0d2679061 |
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| Source note | uspto-grants-1976_07 |
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