Phosphorus tribromide → 1-Bromo-11-methoxy-3,7,11-trimethyldodeca-2,4-diene

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Reaction Steps

To a solution of 1.90 g. of 11-methoxy-3,7,11-trimethyldodeca-2,4-dien-1-ol in 20 ml. of ether is added a solution of 0.80 g. of phosphorus tribromide in 10 ml. of ether, under nitrogen, with stirring at -50°. The reaction mixture is stirred for three hours at -60° to -40° and then poured into ice water, which is then washed with sodium bicarbonate solution water and brine, dried over calcium sulfate and evaporated under reduced pressure to yield 11-methoxy-3,7,11-trimethyldodeca-2,4-dienyl bromide.

Provenance & Evidence