Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-(2-(Imidazo[1,2-a]pyridin-2-yl)ethyl)isoindoline-1,3-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Aminopyridine | HCID 10439 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 2-(4-Bromo-3-oxobutyl)-1H-isoindole-1,3(2H)-dione | HCID 3759744 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-(2-(Imidazo[1,2-a]pyridin-2-yl)ethyl)isoindoline-1,3-dione | HCID 1531269 | 57.7% |
반응 단계
1-Bromo-4-phthalimidobutan-2-one (23.6 g.) was added to a solution of 2-aminopyridine (7.6 g.) and sodium bicarbonate (6.8 g.) in dimethylformamide (100 ml.) and the mixture was heated at 100° for 1 hour. Cooling followed by addition to water and recrystallisation from ethanol afforded 2-(2-phthalimidoethyl)imidazo [1,2-a]-pyridine (13.4 g.) m.p. 181° - 181.5°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03970753 |
| 출처 데이터셋 | uspto-grants-1976_07 |
| ORD ID | ord-c3942212e0a8463c9bd7333b5bba2a5f |
| 출처 메모 | uspto-grants-1976_07 |