2-Aminopyridine → HCID 86733718, compound

HRID 918337Notes

Reaction equation

HRID 918337 reaction equation
[Br:1][CH2:2][C:3](=O)[CH2:4][CH2:5][N:6]([CH3:8])[CH3:7].[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1>C(O)C>[BrH:1].[BrH:1].[CH3:7][N:6]([CH3:8])[CH2:5][CH2:4][C:3]1[N:10]=[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]2[CH:2]=1

Participants

4

Reactant 2

HCID 104392-AminopyridineHCID 13637176HCID 13637176, compound

Product 1

HCID 86733718HCID 86733718, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 1-bromo-4-dimethylaminobutan-2-one (13.8 g.) and 2-aminopyridine (4.7 g.) in ethanol (50 ml.) was heated under reflux for 2 hours. Cooling filtration from 1-methylpyrrolidin-3-one methobromide (5.6 g.) followed by concentration and recrystallisation of the residue from methanol gave 2-(2-dimethylaminoethyl)-imidazo [1,2-a] pyridine dihydrobromide, m.p. 262° - 264°.

Workup

  1. temperatureunder reflux for 2 hours
  2. temperatureCooling
  3. filtrationfiltration from 1-methylpyrrolidin-3-one methobromide (5.6 g.)
  4. concentrationfollowed by concentration and recrystallisation of the residue from methanol

Sources & evidence

ORD record
ord-ef46a78557854053a490069626f95911
Source dataset
uspto-grants-1976_07
Patent number
US03970753

Reaction notes

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