HCID 86733743, compound → HCID 68128669, compound

Participants

Reaction Steps

A solution of 4.4 g of 9-fluoro-11β,17,21-trihydroxy-16α-[2-(tetrahydropyran-2-yloxy)ethoxy]pregn-4-ene-3,20-dione, 21-acetate in 60 ml each of acetic acid and water is stirred for 4 hours and the bulk of the solvent removed in vacuo. The residue is dissolved in chloroform and washed with 5% sodium bicarbonate solution. Drying and solvent removal gives an oil which crystallizes from acetone-hexane to give 2.4 g of 9-fluoro-11β,17,21-trihydroxy-16α-(2-hydroxyethoxy)pregn-4-ene-3,20-dione, 21-acetate, melting point 162°-165°C.

Provenance & Evidence