Hydrochloric Acid → HCID 86733744, compound

Participants

Reaction Steps

A solution of 0.80 g of 9-fluoro-16α-(2-hydroxyethoxy)-11β,17,21-trihydroxypregn-4-ene-3,20-dione, 21-acetate in 10 ml of pyridine is stirred with 0.5 ml of methanesulfonyl chloride for 90 minutes at 0°C under nitrogen. The solution is poured into cold 5% hydrochloric acid and extracted with chloroform. The chloroform extract is dried and evaporated to give an oil which is chromatographed on a 20 g -- silica gel column. Elution with chloroform gives 521 mg of TLC pure 9-fluoro-16α-(2-mesyloxyethoxy)-11β,17,21-trihydroxypregn-4-ene-3,20-dione, 21-acetate.

Provenance & Evidence