HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 86733748, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | HCID 86733749 | HCID 86733749 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 86733748 | HCID 86733748 | — |
Reaction Steps
A solution of 1.5 g of 21-chloro-9-fluoro-11β,17-dihydroxy-16α-(2-hydroxyethoxy)pregna-1,4-diene-3,20-dione in 25 ml of pyridine is cooled to 0°C and 0.6 ml of methanesulfonyl chloride is added. After 2 hours the mixture is poured into cold dilute hydrochloric acid and extracted with chloroform. The chloroform solution is dried and evaporated in vacuo to 2.0 g of crude mesylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03971772 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-a707dce11f674f46bca8e6ea70e85382 |
| Source note | uspto-grants-1976_07 |