4-Chloro-6,7-dimethoxyquinazoline → HCID 21520958, compound

HRID 918388Notes

Reaction equation

HRID 918388 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2Cl.[CH3:16][NH:17][CH2:18][CH:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1)[CH3:20]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2[N:17]([CH2:18][CH:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1)[CH3:20])[CH3:16]

Participants

3

Reactant 2

HCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 12914590HCID 12914590, compound

Product 1

HCID 21520958HCID 21520958, compound

Procedure

Reaction of 6,7-dimethoxy-4-chloroquinazoline with 2-(1-[N-methylamino]prop-2-yl)pyridine, according to the procedure of Example I, afforded the title compound, isolated as its dihydrochloride trihydrate, m.p. 235°C.

Sources & evidence

ORD record
ord-b9a146d7061e4eb3b45e31b58439da75
Source dataset
uspto-grants-1976_07
Patent number
US03971783

Reaction notes

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