反应详情

4-(7-Chloro-4-quinolylamino) benzoyl chloride hydrochloride (prepared by refluxing 9.0 grams of 4-(7-chloro-4-quinolylamino) benzoic acid and evaporating the excess thionyl chloride, was added in portions to a cooled, stirred mixture of 4.32 grams of N,N,N1 -triethylethylene diamine and 32 grams of sodium carbonate in 60 milliliters of chloroform and 70 milliliters of water. After stirring for 2 days at room temperature the reaction mixture was filtered, the chloroform layer separated, dried and evaporated to give an oil. This was triturated with hexane to give a light brown solid, which was triturated with acetone to give 5.3 grams of the title compound as a quarter hydrate.

1. customevaporating the excess thionyl chloride
2. additionwas added in portions to a cooled
3. additionmixture of 4.32 grams of N,N,N1 -triethylethylene diamine and 32 grams of sodium carbonate in 60 milliliters of chloroform and 70 milliliters of water
4. stirringAfter stirring for 2 days at room temperature the reaction mixture
5. filtrationwas filtered
6. customthe chloroform layer separated
7. customdried
8. customevaporated
9. customto give an oil
10. customThis was triturated with hexane
11. customto give a light brown solid, which
12. customwas triturated with acetone