HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-(2-Diazoethoxy)oxane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | N-Nitroso-N-{2-[(oxan-2-yl)oxy]ethyl}urea | HCID 12850117 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Pentane | HCID 8003 | — |
| Product | 2-(2-Diazoethoxy)oxane | HCID 21520879 | — |
Reaction Steps
A solution of 41.8 g of N-nitroso-N-[2-(tetrahydropyran-2-yloxy)ethyl]urea in 200 ml of ether and 100 ml of pentane is added to 450 ml of 1N sodium hydroxide solution at 1°-4°C over a 25 minute period. The solution is stirred for an additional 30 minutes and the layers are separated. The organic layer is dried over sodium hydroxide pellets at 20°C for 5 minutes, and then filtered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03971773 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-c6d1dfda6f174052997187d1696d498c |
| Source note | uspto-grants-1976_07 |