HuagongsheHuagongshe Chemistry Print Report · For research reference only
Urea, (2,2-diethoxyethyl)- → 21-Chloro-16alpha-(2,2-diethoxyethoxy)-11beta,17-dihydroxypregna-1,4-diene-3,20-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Urea, (2,2-diethoxyethyl)- | HCID 1713901 | — |
| Reactant | Ethane, 2-diazo-1,1-diethoxy- | HCID 21520892 | — |
| Reactant | 21-Chloro-11beta,16alpha,17-trihydroxypregna-1,4-diene-3,20-dione | HCID 86733753 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 21-Chloro-16alpha-(2,2-diethoxyethoxy)-11beta,17-dihydroxypregna-1,4-diene-3,20-dione | HCID 86733752 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
A solution of 2,2-diethoxy-1-diazoethane (prepared from 0.0935 mole of N-2,2-diethoxyethyl urea by the method of W. Kirmse and M. Buschhoff, Chem. Ber., 100, 1491 (1967)) in 300 ml of 3:2 ether-pentane is diluted with 100 ml of methanol and cooled to 0°C. 21-Chloro-11β,16α,17-trihydroxypregna-1,4-diene-3,20-dione, 16,17-cycloborate is added in portions until nitrogen evolution ceases. The solvent is removed in vacuo to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03971773 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-2d813c81b2a043a78d6f4aae31eea7e8 |
| Source note | uspto-grants-1976_07 |