Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 918407Generated: October 31, 2026

16alpha-Hydroxyprednisolone → 11beta,17,21-Trihydroxy-16alpha-(2-phenyl-2-propenyloxy)-pregna-1,4-diene-3,20-dione

https://huagongshe.com/reaction/918407

Reaction equation

Participants

RoleNameHCIDCharge
Reactant16alpha-HydroxyprednisoloneHCID 11047056—
Reactant(3-Diazoprop-1-en-2-yl)benzeneHCID 21520875—
Product11beta,17,21-Trihydroxy-16alpha-(2-phenyl-2-propenyloxy)-pregna-1,4-diene-3,20-dioneHCID 68142405—

Reaction Steps

A solution of 1-diazo-2-phenyl-2-propene (prepared from 0.3 mole of N-nitrosourethane precursor) in methanolether at 0° is treated with 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, 16,17-cycloborate (84 mmoles) until nitrogen evolution ceases. Solvent removal gives the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03971773
Source datasetuspto-grants-1976_07
ORD IDord-2f60fa2f69f54321895e974f942ef05a
Source noteuspto-grants-1976_07