Hydrochloric Acid → HCID 86733757, compound

Participants

Reaction Steps

A solution of 21-chloro-17-hydroxy-16α-(2-oxopropoxy)pregna-1,4,9(11)-triene-3,20-dione (4mmoles) and 7.2 g of lithium chloride in 72 ml of glacial acetic acid is stirred at 0°-5°C and 592 mg of N-chlorosuccinimide is added. A solution of 180 mg of dry hydrogen chloride in 2.9 ml of tetrahydrofuran is added and the resulting mixture stirred at room temperature for 2 hours, poured into 400 ml of cold water, and extracted with chloroform. The chloroform solution is washed with water, dried, and evaporated to give the title compound.

Provenance & Evidence