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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 918412Generated: November 3, 2026

11beta,16alpha,17,21-Tetrahydroxypregn-4-ene-3,20-dione → 16alpha-Allyloxy-11beta,17,21-trihydroxypregn-4-ene-3,20-dione

https://huagongshe.com/reaction/918412

Reaction equation

Participants

RoleNameHCIDCharge
Reactant11beta,16alpha,17,21-Tetrahydroxypregn-4-ene-3,20-dioneHCID 102003—
Reactant1-Diazo-2-propeneHCID 10909479—
Product16alpha-Allyloxy-11beta,17,21-trihydroxypregn-4-ene-3,20-dioneHCID 68142700—

Reaction Steps

11β,16α,17,21-Tetrahydroxypregn-4-ene-3,20-dione, 16,17-cycloborate is added to a solution of vinyl diazomethane in 1:1 methanol-ether at 0°C until nitrogen evolution ceases. The solvent is evaporated to yield the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03971773
Source datasetuspto-grants-1976_07
ORD IDord-8f961c0811564b9cb71dcafe6a28802f
Source noteuspto-grants-1976_07