m-Chloroperbenzoic acid → 21-Chloro-11beta,17-dihydroxy-16alpha-(oxiranylmethoxy)-pregn-4-ene-3,20-dione

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Reaction Steps

A solution of 16α-allyloxy-21-chloro-11β,17-dihydroxypregn-4-ene-3,20-dione (3.8 mmoles) in 50 ml of dichloromethane is stirred with 0.76 g of m-chloroperbenzoic acid for 19 hours at room temperature. The resulting solution is washed with a mixture of 10% potassium carbonate solution and 10% sodium sulfite solution, dried, and evaporated in vacuo to yield the title compound.

Provenance & Evidence