HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Diazoethoxy)oxane → 21-Chloro-11beta,17-dihydroxy-16alpha-[2-(tetrahydropyran-2-yloxy)ethoxy]-pregna-1,4-diene-3,20-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Diazoethoxy)oxane | HCID 21520879 | — |
| Reactant | 21-Chloro-11beta,16alpha,17-trihydroxypregna-1,4-diene-3,20-dione | HCID 86733753 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 21-Chloro-11beta,17-dihydroxy-16alpha-[2-(tetrahydropyran-2-yloxy)ethoxy]-pregna-1,4-diene-3,20-dione | HCID 22791782 | — |
Reaction Steps
A solution of 2-(tetrahydropyran-2-yloxy)-1-diazoethane (prepared from 0.21 mole of N-[2-(tetrahydropyran-2-yloxy)ethyl]urea as described in Example 1) in 400 ml of 3:1 ether-pentane is diluted with 100 ml each of ether and methanol at 0°C and stirred vigorously while 21-chloro-11β,16α,17-trihydroxypregna-1,4-diene-3,20-dione, 16,17-cycloborate (12 mmoles) is added. After nitrogen evolution ceases the solvents are removed in vacuo to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03971773 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-9c873323b49c432aba26e9e91a416864 |
| Source note | uspto-grants-1976_07 |