HuagongsheHuagongshe Chemistry Print Report · For research reference only
21-Chloro-11beta,17-dihydroxy-16alpha-[2-(tetrahydropyran-2-yloxy)ethoxy]-pregna-1,4-diene-3,20-dione → 21-Chloro-11beta,17-dihydroxy-16alpha-(2-hydroxyethoxy)pregna-1,4-diene-3,20-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 21-Chloro-11beta,17-dihydroxy-16alpha-[2-(tetrahydropyran-2-yloxy)ethoxy]-pregna-1,4-diene-3,20-dione | HCID 22791782 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | 21-Chloro-11beta,17-dihydroxy-16alpha-(2-hydroxyethoxy)pregna-1,4-diene-3,20-dione | HCID 86733760 | — |
Reaction Steps
A solution of 21-chloro-11β,17-dihydroxy-16α-[2-(tetrahydropyran-2-yloxy)ethoxy]pregna-1,4-diene-3,20-dione (8.4 mmoles) in 50 ml of acetic acid and 50 ml of water is stirred at room temperature for 6 hours, diluted with cold water, and the resulting solid filtered and dried in vacuo to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03971773 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-653cfec4b7934e5faae72f807aa48766 |
| Source note | uspto-grants-1976_07 |