HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 21-Chloro-11beta,17-dihydroxy-16alpha-(2-mesyloxyethoxy)pregna-1,4-diene-3,20-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 21-Chloro-11beta,17-dihydroxy-16alpha-(2-hydroxyethoxy)pregna-1,4-diene-3,20-dione | HCID 86733760 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 21-Chloro-11beta,17-dihydroxy-16alpha-(2-mesyloxyethoxy)pregna-1,4-diene-3,20-dione | HCID 86733761 | — |
Reaction Steps
A solution of 21-chloro-11β,17-dihydroxy-16α-(2-hydroxyethoxy)pregna-1,4-diene-3,20-dione (7.6 mmoles) in 30 ml of pyridine is cooled to 0°C and 1 ml of methanesulfonyl chloride is added. After 2 hours the mixture is poured into cold dilute hydrochloric acid and extracted with chloroform. The chloroform solution is dried and evaporated in vacuo to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03971773 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-ce70573a3aed435a8288f2b2e7890bd9 |
| Source note | uspto-grants-1976_07 |